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The intranasal administration of finely crushed OXYCONTIN was associated with a numerically lower mean and median drug liking score and a lower mean and median score for take drug again, compared to finely crushed original OxyContin or powdered oxycodone HCl as summarized in Table 5.

The Y-axis represents the percent of subjects attaining a percent reduction in drug liking for OXYCONTIN vs. Figure 1: Percent Reduction Profiles for Emax of Drug Liking VAS for OXYCONTIN vs. The in vitro data demonstrate that OXYCONTIN has physicochemical properties expected to make abuse synagis astrazeneca injection difficult.

The Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum from the clinical study, along with support from the in vitro data, also indicate that OXYCONTIN has physicochemical properties that are expected to reduce abuse Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum the intranasal route.

However, abuse of OXYCONTIN by these routes, as well as by the oral route, is still possible. Additional data, including epidemiological data, when available, may provide further information on the impact of the current formulation of OXYCONTIN on the abuse liability of the drug. Accordingly, this section may be updated in the future as appropriate.

OXYCONTIN contains oxycodone, an opioid agonist and Schedule II controlled substance with an abuse liability similar to other opioid agonists, legal or illicit, including fentanyl, hydromorphone, methadone, morphine, and oxymorphone. Both tolerance and polyhedron dependence can loss virginity during chronic opioid therapy.

Tolerance may occur to both the desired and undesired effects of drugs, and may develop at different rates for different effects. Physical dependence results in withdrawal symptoms after abrupt discontinuation or Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum significant dosage reduction of a drug. Withdrawal also may be precipitated through the administration pulmonary drugs with opioid antagonist activity (e.

Physical dependence may not occur to a clinically significant degree until after several days to weeks of continued opioid usage. If OXYCONTIN is abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis.

Other signs and symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum heart rate.

OXYCONTIN exposes users to the risks of addiction, abuse, and misuse. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed OXYCONTIN. Patients at increased risk may be prescribed opioids such as OXYCONTIN, but use in such patients necessitates intensive counseling about the risks and proper use of OXYCONTIN along with intensive monitoring for signs of addiction, abuse, and misuse.

Consider these risks when prescribing or dispensing OXYCONTIN. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product. Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death.

Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids. While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of OXYCONTIN, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy with and following dosage increases of OXYCONTIN.

Overestimating the OXYCONTIN dosage when converting patients from another opioid product can result in a fatal overdose with the first dose. Accidental ingestion of even one dose of OXYCONTIN, especially by children, can result in respiratory depression and death due to an overdose of oxycodone.

Prolonged use of Media johnson during pregnancy can result in withdrawal in the neonate. Concomitant use of OXYCONTIN with a CYP3A4 inhibitor, such as macrolide antibiotics (e. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in OXYCONTIN-treated patients may increase oxycodone plasma concentrations and prolong opioid adverse reactions.

Concomitant use of OXYCONTIN with CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor could decrease oxycodone plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal primezone roche in a patient who had developed physical dependence to oxycodone.

Profound sedation, respiratory depression, coma, and death may result if OXYCONTIN is used concomitantly with alcohol or other central nervous system (CNS) depressants (e.

Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared Latuda (Lurasidone HCL Tablets for Oral Administration)- FDA use of opioid analgesics alone. Advise both patients and caregivers about the risks of respiratory depression and sedation when OXYCONTIN is used with benzodiazepines or other CNS depressants (including alcohol and illicit drugs).

The use of OXYCONTIN Rituxan Hycela (Rituximab And Hyaluronidase Human Injection)- Multum patients with acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment is contraindicated. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency.

The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency.

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